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KMID : 0614020080230010025
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Journal of Pharmaceutical Sciences (C.N.U.)
2008 Volume.23 No. 1 p.25 ~ p.33
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The Application Modes of Microneedles for Enhancement of Transdermal Drug Delivery
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Son Baik-Lark
Kim Dong-Chool
Cho Cheong-Weon
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Abstract
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Despite the advantages of drug delivery through the skin, such as easy accessibility, convenience, prolonged therapy, avoidance of the liver first-pass metabolism and a large surface area, transdermal drug delivery is only used with a small subset of drugs because most compounds cannot cross the skin at therapeutically useful rates. Recently, a new concept was introduced known as microneedles and could be pierced to effectively deliver drugs using microsized needles in a minimally invasive and painless manner. This review suggests that a biocompatible microneedle might be a suitable tool for transdermal drug delivery system of hydrophilic molecules with possible applications to macromolecules such as proteins and peptides.
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KEYWORD
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microneedle, transdermal drug delivery, proteins and peptides, vaccine
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